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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927086Generated: October 26, 2026

1-Chloro-4-iodobenzene → 3,4-Bis(benzyloxy)-6-((4-chlorophenyl)ethynyl)pyridazine

https://huagongshe.com/reaction/927086

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-4-iodobenzeneHCID 12510—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-Bis(benzyloxy)-6-((4-chlorophenyl)ethynyl)pyridazineHCID 7126979570%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-chloro-4-iodobenzene in 70% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-382f30dd71f3471488e732b533de5ebc
Source noteuspto-grants-2016_03