Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927087Generated: November 2, 2026

1-Chloro-2-iodobenzene → 3,4-Bis(benzyloxy)-6-((2-chlorophenyl)ethynyl)pyridazine

https://huagongshe.com/reaction/927087

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-2-iodobenzeneHCID 11993—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-Bis(benzyloxy)-6-((2-chlorophenyl)ethynyl)pyridazineHCID 7127013659%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-chloro-2-iodobenzene in 59% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-74e5846913aa4de2bf3a32f4cf12e550
Source noteuspto-grants-2016_03