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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927088Generated: October 31, 2026

1-(Difluoromethoxy)-4-iodobenzene → 3,4-Bis(benzyloxy)-6-((4-(difluoromethoxy)phenyl)ethynyl)pyridazine

https://huagongshe.com/reaction/927088

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Difluoromethoxy)-4-iodobenzeneHCID 2737008—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-Bis(benzyloxy)-6-((4-(difluoromethoxy)phenyl)ethynyl)pyridazineHCID 7127024858%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-(difluoromethoxy)-4-iodobenzene in 58% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-2ddf464df1ff4ca28aba483da4d66ec4
Source noteuspto-grants-2016_03