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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927089Generated: November 1, 2026

1-Iodo-4-(trifluoromethoxy)benzene → 3,4-Bis(benzyloxy)-6-((4-(trifluoromethoxy)phenyl)ethynyl)pyridazine

https://huagongshe.com/reaction/927089

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Iodo-4-(trifluoromethoxy)benzeneHCID 2777294—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-Bis(benzyloxy)-6-((4-(trifluoromethoxy)phenyl)ethynyl)pyridazineHCID 71270488—

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-iodo-4-(trifluoromethoxy)benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-11a01a64ffe24238afebed00f100c17e
Source noteuspto-grants-2016_03