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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927090Generated: November 1, 2026

1-(difluoromethoxy)-3-iodobenzene → HCID 71270415, compound

https://huagongshe.com/reaction/927090

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(difluoromethoxy)-3-iodobenzeneHCID 2774115—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
ProductHCID 71270415HCID 7127041587%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-(difluoromethoxy)-3-iodobenzene in 87% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-07343138fcf24cf391281053b9f70fde
Source noteuspto-grants-2016_03