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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927091Generated: October 27, 2026

3,4-Bis(benzyloxy)-6-chloropyridazine → 3,4-bis(Benzyloxy)-6-{2-(3-(trifluoromethoxy)phenyl)-ethynyl}pyridazine

https://huagongshe.com/reaction/927091

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Bis(benzyloxy)-6-chloropyridazineHCID 12213474—
Reactant3-(Trifluoromethoxy)PhenylacetyleneHCID 26986262—
Reactant3,4-Bis(benzyloxy)-6-(phenylethynyl)pyridazineHCID 71270419—
Product3,4-bis(Benzyloxy)-6-{2-(3-(trifluoromethoxy)phenyl)-ethynyl}pyridazineHCID 7126987937%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-(phenylethynyl)pyridazine (Intermediate 2) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and 1-ethynyl-3-(trifluoromethoxy)benzene in 37% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-7f8d046e663a464dbaa3e5499c00b471
Source noteuspto-grants-2016_03