Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927097Generated: October 25, 2026

3,4-Bis(benzyloxy)-6-chloropyridazine → 5,6-bis(Benzyloxy)-N-(cyclopropylmethyl)-N-methylpyridazin-3-amine

https://huagongshe.com/reaction/927097

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Bis(benzyloxy)-6-chloropyridazineHCID 12213474—
Reactant(Cyclopropylmethyl)methylamineHCID 12919209—
Reactant5,6-bis(Benzyloxy)-N-[(4-fluorophenyl)methyl]pyridazin-3-amineHCID 71269907—
Product5,6-bis(Benzyloxy)-N-(cyclopropylmethyl)-N-methylpyridazin-3-amineHCID 7127054417%

Reaction Steps

Prepared as described for 5,6-bis(benzyloxy)-N-[(4-fluorophenyl)methyl]pyridazin-3-amine (Intermediate 45) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and 1-cyclopropyl-N-methylmethanamine in 17% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-a3b5ebc7f78241a79debd33617883d83
Source noteuspto-grants-2016_03