Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927106Generated: October 25, 2026

3,4-Bis(benzyloxy)-6-chloropyridazine → 3,4-bis(Benzyloxy)-6-[(2-fluorophenyl)methyl]pyridazine

https://huagongshe.com/reaction/927106

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Bis(benzyloxy)-6-chloropyridazineHCID 12213474—
Reactant3,4-bis(Benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazineHCID 71270427—
ReactantHCID 178505630HCID 178505630—
Product3,4-bis(Benzyloxy)-6-[(2-fluorophenyl)methyl]pyridazineHCID 7127019277%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine (Intermediate 51) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and (2-fluorobenzyl)zinc(II) chloride in 77% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-f08acde113a44ed89de214b6f114ce7b
Source noteuspto-grants-2016_03