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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927119Generated: October 25, 2026

4-Bromo-3-fluorobenzotrifluoride → 3,4-bis(Benzyloxy)-6-{2-[2-fluoro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazine

https://huagongshe.com/reaction/927119

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-3-fluorobenzotrifluorideHCID 142414—
Reactant3,4-Bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazineHCID 71269897—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-bis(Benzyloxy)-6-{2-[2-fluoro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazineHCID 7127051116%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazine (Intermediate 74) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-bromo-2-fluoro-4-(trifluoromethyl)benzene in 16% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-47ade3eda15144e2a56378d05b86e767
Source noteuspto-grants-2016_03