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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927120Generated: November 3, 2026

3,4-Bis(benzyloxy)-6-chloropyridazine → 3,4-bis(Benzyloxy)-6-[(E)-2-[3,5-bis(trifluoromethyl)phenyl]-ethenyl]pyridazine

https://huagongshe.com/reaction/927120

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Bis(benzyloxy)-6-chloropyridazineHCID 12213474—
Reactant2-{(E)-2-[3,5-Bis(trifluoromethyl)phenyl]ethenyl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 16218190—
ReactantHCID 86677027HCID 86677027—
Product3,4-bis(Benzyloxy)-6-[(E)-2-[3,5-bis(trifluoromethyl)phenyl]-ethenyl]pyridazineHCID 8667703577%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-(1-phenylethenyl)pyridazine (Intermediate 25) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and 2-[(E)-2-[3,5-bis(trifluoromethyl)phenyl]ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in 77% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-eea7a35801384681b1e27b46a9e2e557
Source noteuspto-grants-2016_03