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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927123Generated: October 25, 2026

4-Bromo-2-chlorobenzotrifluoride → 3,4-bis(Benzyloxy)-6-{2-[3-chloro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazine

https://huagongshe.com/reaction/927123

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Bromo-2-chlorobenzotrifluorideHCID 20269848—
Reactant3,4-Bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)phenyl)-ethynyl)pyridazineHCID 71269897—
Product3,4-bis(Benzyloxy)-6-{2-[3-chloro-4-(trifluoromethyl)phenyl]-ethynyl}pyridazineHCID 7127016298%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-((3-methyl-4-(trifluoromethyl)-phenyl)ethynyl)pyridazine (Intermediate 74) using 4-bromo-2-chloro-1-(trifluoro-methyl)benzene in 98% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-9361347584cf4d1d8e35e825edf6496c
Source noteuspto-grants-2016_03