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HRID 927131作成日：2026年10月26日

3,4-bis(Benzyloxy)-6-[(3-fluorophenyl)ethynyl]pyridazine → HCID 178518815、化合物

https://huagongshe.com/reaction/927131

反応式

関与物質

役割名称HCID仕込み量
反応物3,4-bis(Benzyloxy)-6-[(3-fluorophenyl)ethynyl]pyridazineHCID 71270240—
溶媒MethanolHCID 887—
生成物HCID 178518815HCID 17851881563%

反応手順

Prepared as described for 4-hydroxy-6-(2-phenethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(3-fluorophenyl)ethynyl]pyridazine (Intermediate 10) except that the reaction was carried out in methanol. The resulting crude product was recrystallised from a mixture of ethanol and heptane to afford 6-[2-(3-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one as cream crystals (yield=63%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09290456B2
出典データセットuspto-grants-2016_03
ORD IDord-ba543bd33a474121bcbd6ad90c0cb7cd
出典メモuspto-grants-2016_03