HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-bis(Benzyloxy)-6-(cyclopropylethynyl)pyridazine → HCID 178518807, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-bis(Benzyloxy)-6-(cyclopropylethynyl)pyridazine | HCID 71270471 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178518807 | HCID 178518807 | 14% |
Reaction Steps
Prepared as described for 4-hydroxy-6-(2-phenethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-(cyclopropylethynyl)pyridazine (Intermediate 18) except that the reaction was carried out in ethanol. The resulting crude product was purified by preparative HPLC under acidic conditions to afford 6-(2-cyclopropylethyl)-4-hydroxypyridazin-3(2H)-one as a cream solid (14% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290456B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-416ad1f0ab464eac880f95009172fd39 |
| Source note | uspto-grants-2016_03 |