3,4-bis(Benzyloxy)-6-{2-(3-(trifluoromethoxy)phenyl)-ethynyl}pyridazine → HCID 178518827, compound

HRID 927145Notes

Reaction equation

HRID 927145 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([O:47][C:48]([F:51])([F:50])[F:49])[CH:42]=2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>C(O)C>[OH:31][C:30]1[C:25](=[O:24])[NH:26][N:27]=[C:28]([CH2:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([O:47][C:48]([F:50])([F:49])[F:51])[CH:42]=2)[CH:29]=1

Participants

4

Reactant 2

HCID 712698793,4-bis(Benzyloxy)-6-{2-(3-(trifluoromethoxy)phenyl)-ethynyl}pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518827HCID 178518827, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-((3(trifluoromethoxy)phenyl)ethynyl)pyridazine (Intermediate 39) except that the solvent used for the hydrogenation was ethanol and the final compound was recrystallised from a mixture of ethyl acetate and heptane.

Workup

  1. customthe final compound was recrystallised from a mixture of ethyl acetate and heptane

Sources & evidence

ORD record
ord-cb9031f628cb4b9ebd6918a48c507803
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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