3,4-Bis(benzyloxy)-6-((2-trifluoromethylphenyl)ethynyl)pyridazine → HCID 178518810, compound

HRID 927148Notes

Reaction equation

HRID 927148 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[C:47]([F:50])([F:49])[F:48])=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>>[OH:31][C:30]1[C:25](=[O:24])[NH:26][N:27]=[C:28]([CH2:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=2[C:47]([F:49])([F:48])[F:50])[CH:29]=1

Participants

3

Reactant 2

HCID 712703513,4-Bis(benzyloxy)-6-((2-trifluoromethylphenyl)ethynyl)pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518810HCID 178518810, compound

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-((2-trifluoromethylphenyl)ethynyl)pyridazine (Intermediate 40) except that the final product was recrystallised from a mixture of ethyl acetate and heptane.

Sources & evidence

ORD record
ord-25d125c53e3d4153876cdf14cb35708b
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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