HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-bis(Benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine → 6-(4-Fluorobenzyl)-4-hydroxypyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-bis(Benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine | HCID 71270427 | — |
| Reactant | 3-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One | HCID 178518808 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(4-Fluorobenzyl)-4-hydroxypyridazin-3(2H)-one | HCID 178518800 | — |
Reaction Steps
Prepared in the same way as 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(4-fluorophenyl)methyl]pyridazine (Intermediate 51) except that the solvent used for the hydrogenation was ethyl acetate and the product was recrystallised from a mixture of MTBE and heptanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290456B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c0f5c55f6103409eb25ba82de56a575a |
| Source note | uspto-grants-2016_03 |