HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-bis(Benzyloxy)-6-[(2-chlorophenyl)methyl]pyridazine → 6-(2-Chlorobenzyl)-4-hydroxypyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-bis(Benzyloxy)-6-[(2-chlorophenyl)methyl]pyridazine | HCID 71270197 | — |
| Reactant | 3-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One | HCID 178518808 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-(2-Chlorobenzyl)-4-hydroxypyridazin-3(2H)-one | HCID 178518794 | — |
Reaction Steps
Prepared in the same way as 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(2-chlorophenyl)methyl]pyridazine (Intermediate 53) except that the solvent used for the hydrogenation was tetrahydrofuran and the product was recrystallised from a mixture of MTBE and heptanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290456B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-6d1cf828d35a4d49a0c8c96e4cb1275f |
| Source note | uspto-grants-2016_03 |