HCID 71269878, compound → HCID 178518836, compound

HRID 927172Notes

Reaction equation

HRID 927172 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]#[C:40][C:41]2[C:46]([F:47])=[CH:45][CH:44]=[CH:43][C:42]=2[Cl:48])=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>[Pt]=O.CO>[Cl:48][C:42]1[CH:43]=[CH:44][CH:45]=[C:46]([F:47])[C:41]=1[CH2:40][CH2:39][C:28]1[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=1

Participants

5

Reactant 2

HCID 71269878HCID 71269878, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518836HCID 178518836, compoundYield 24.8%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[2-(2-chloro-6-fluorophenyl)ethynyl]pyridazine (Intermediate 32) except that the catalyst used for the hydrogenation was platinum oxide and the solvent was methanol and the final material was purified by preparative HPLC (0.035 g, 24.8% yield).

Workup

  1. customthe final material was purified by preparative HPLC (0.035 g, 24.8% yield)

Sources & evidence

ORD record
ord-7d347043a469454d931e432ae61408f5
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

Loading…