3,4-bis(Benzyloxy)-6-{1-[4-(trifluoromethyl)phenyl]-cyclopropyl}pyridazine → HCID 178518784, compound

HRID 927176Notes

Reaction equation

HRID 927176 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28]([C:39]2([C:42]3[CH:47]=[CH:46][C:45]([C:48]([F:51])([F:50])[F:49])=[CH:44][CH:43]=3)[CH2:41][CH2:40]2)=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>>[OH:31][C:30]1[C:25](=[O:24])[NH:26][N:27]=[C:28]([C:39]2([C:42]3[CH:47]=[CH:46][C:45]([C:48]([F:50])([F:49])[F:51])=[CH:44][CH:43]=3)[CH2:40][CH2:41]2)[CH:29]=1

Participants

3

Reactant 2

HCID 712703283,4-bis(Benzyloxy)-6-{1-[4-(trifluoromethyl)phenyl]-cyclopropyl}pyridazine2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518784HCID 178518784, compoundYield 20%

Procedure

Prepared in the same manner as 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-{1-[4-(trifluoromethyl)phenyl]-cyclopropyl}-pyridazine (Intermediate 68) in 20% yield.

Sources & evidence

ORD record
ord-d3bb189e57e44eedbefb0b2f2b18c25f
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

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