HCID 86677041, compound → HCID 178518817, compound

HRID 927180Notes

Reaction equation

HRID 927180 reaction equation
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C([O:24][C:25]1[N:26]=[N:27][C:28](/[CH:39]=[CH:40]/[C:41]2[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][C:42]=2[C:51]([F:54])([F:53])[F:52])=[CH:29][C:30]=1[O:31]CC1C=CC=CC=1)C1C=CC=CC=1>>[F:54][C:51]([F:52])([F:53])[C:42]1[CH:43]=[C:44]([C:47]([F:48])([F:50])[F:49])[CH:45]=[CH:46][C:41]=1[CH2:40][CH2:39][C:28]1[CH:29]=[C:30]([OH:31])[C:25](=[O:24])[NH:26][N:27]=1

Participants

3

Reactant 2

HCID 86677041HCID 86677041, compound2×HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

Product 1

HCID 178518817HCID 178518817, compoundYield 31%

Procedure

Prepared as described for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-[(E)-2-[2,4-bis(trifluoromethyl)phenyl]-ethenyl]pyridazine (Intermediate 72) in 31% yield.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fd80e1751a864e1eb5f47ea0113597ce
Source dataset
uspto-grants-2016_03
Patent number
US09290456B2

Reaction notes

Loading…