Sodium hydride → HCID 90095750, compound

Participants

Reaction Conditions

Reaction Steps

NaH (0.382 g, 9.56 mmol) was added to a stirred, 0° C. mixture of dimethyl 2-(2-((4-fluorophenyl)amino)-2-oxoethyl)terephthalate (1.65 g, 4.78 mmol) in tetrahydrofuran (100 mL) and the mixture was stirred at 0° C. for 90 min. which turned into a red solution. The mixture was diluted with ethyl acetate (30 mL), washed with hydrochloric acid (0.5 M, 1×15 mL), water (10 mL), and brine (20 mL), dried (MgSO4), filtered and the solvent was evaporated under reduced pressure to give methyl 2-(4-fluorophenyl)-1,3-dioxo-1,2,3,4-tetrahydroisoquinoline-6-carboxylate (1.5 g, 4.79 mmol) as a white solid.

Provenance & Evidence