HCID 68388650, compound → 5-[[2,4-Dioxo-3,4-dihydroquinazolin-1(2H)-yl]methyl]-2-fluorobenzoic Acid

HRID 927295Notes

Reaction equation

HRID 927295 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][N:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:17])[NH:9][C:8]2=[O:18])=[CH:4][C:3]=1[C:21]([O:23]C)=[O:22].C(C1C=C(C=CC=1)CN1C2C(=CC=CC=2)C(=O)NC1=O)(O)=O>>[C:21]([C:3]1[CH:4]=[C:5]([CH:19]=[CH:20][C:2]=1[F:1])[CH2:6][N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10](=[O:17])[NH:9][C:8]1=[O:18])([OH:23])=[O:22]

Participants

3

Reactant 2

HCID 68388650HCID 68388650, compoundHCID 683887821-(3-Carboxybenzyl)quinazoline-2,4(1H,3H)-dione

Product 1

HCID 683593335-[[2,4-Dioxo-3,4-dihydroquinazolin-1(2H)-yl]methyl]-2-fluorobenzoic Acid

Procedure

The title compound was prepared from 1-(4-fluoro-3-methoxycarbonylbenzyl)quinazoline-2,4(1H,3H)-dione using a procedure similar to those described for the synthesis of compound of Example 2. 1H NMR (DMSO-d6): 13.23 (brs, 1H), 11.75 (s, 1H), 8.00 (d, J=7.5 Hz, 1H), 7.80 (dd, J=6.9 and 2.1 Hz, 1H), 7.67-7.54 (m, 2H), 7.30-7.21 (m, 3H), 5.31 (s, 2H). MS: m/z 315.3 [M+H]+.

Sources & evidence

ORD record
ord-0d22d926b4514c96b3478d9b23829207
Source dataset
uspto-grants-2016_03
Patent number
US09290460B2

Reaction notes

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