HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quinazolinedione → 1-(4-Chloro-3-(4-(cyclohexylcarbonyl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quinazolinedione | HCID 64048 | — |
| Reactant | Ethyl 5-(chloromethyl)-2-furancarboxylate | HCID 263166 | — |
| Reactant | HCID 68388893 | HCID 68388893 | — |
| Reactant | 1-((2-carboxy-furan-5-yl)methyl)quinazoline-2,4(1H,3H)-dione | HCID 68389026 | — |
| Product | 1-(4-Chloro-3-(4-(cyclohexylcarbonyl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione | HCID 68388738 | — |
Reaction Steps
The following compounds were prepared from 1-((2-carboxy-furan-5-yl)methyl)quinazoline-2,4(1H,3H)-dione (prepared from quinazoline-2,4(1H,3H)-dione and ethyl 5-(chloromethyl)furan-2-carboxylate using a procedure similar to those described for the synthesis of compounds of Example 1 and 2), and the corresponding substituted piperazine using a procedure similar to those described for the synthesis of compound of Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290460B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-b8d6ff7b9fa34dc0b1c5f8c76257b8ea |
| Source note | uspto-grants-2016_03 |