1-Bromohexane → HCID 68419578, compound

Participants

Reaction Steps

[3-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)propyl]-{4-[3-(2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)propylamino]butyl}carbamic acid tert-butyl ester (2 g, 3.4 mmol) was dissolved in 40 mL tetrahydrofuran. Sodium hydride (0.16 g, 6.7 mmol) and 1-bromohexane (0.67 g, 4.0 mmol) were added thereto and stirred under reflux. The solvent was concentrated under reduced pressure, and silica gel column-chromatography of the remaining residue was performed to give the title compound of white solid (0.52 g, 23%).

Provenance & Evidence