6-(3-Chlorophenyl)picolinic acid → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

HRID 927360Notes

Reaction equation

HRID 927360 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][C:18]([CH3:25])([C:20]1[S:21][CH:22]=[CH:23][N:24]=1)[NH2:19]>>[CH3:17][C:18]([NH:19][C:14]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:20]1[S:21][CH:22]=[CH:23][N:24]=1)[CH3:25]

Participants

3

Reactant 2

HCID 247301356-(3-Chlorophenyl)picolinic acidHCID 282862032-(1,3-Thiazol-2-yl)propan-2-amine

Product 1

HCID 711055386-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (LC/MS): 358.0 [M+H]+.

Sources & evidence

ORD record
ord-ba405ff2e5f540de9aeb08c718264bb3
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

Loading…