6-(3-Chlorophenyl)picolinic acid → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-dimethylcarbamoyl-1-ethyl-propyl)-amide

HRID 927380Notes

Reaction equation

HRID 927380 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH2:17][C:18]([CH2:26][CH3:27])([CH2:24][CH3:25])[C:19]([N:21]([CH3:23])[CH3:22])=[O:20]>>[CH3:23][N:21]([CH3:22])[C:19]([C:18]([NH:17][C:14]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([CH2:24][CH3:25])[CH2:26][CH3:27])=[O:20]

Participants

3

Reactant 2

HCID 247301356-(3-Chlorophenyl)picolinic acidHCID 798102892-amino-2-ethyl-N,N-dimethyl-butyramide

Product 1

HCID 711055436-(3-Chloro-phenyl)-pyridine-2-carboxylic acid (1-dimethylcarbamoyl-1-ethyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and 2-amino-2-ethyl-N,N-dimethyl-butyramide as starting materials, MS (EI): 374.2 [M+H]+.

Sources & evidence

ORD record
ord-5b806a6cd32b4f72a0d692b61c3c30d1
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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