1-Aminopiperidine → 6-Cyclohexyl-pyridine-2-carboxylic acid piperidin-1-ylamide

HRID 927381Notes

Reaction equation

[CH:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=O)[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[N:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[N:16]1([NH:22][C:13]([C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[N:12]=2)=[O:15])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

Reactant 2

HCID 166581-Aminopiperidine

HCID 681621566-Cyclohexyl-pyridine-2-carboxylic acid

Product 1

HCID 710875846-Cyclohexyl-pyridine-2-carboxylic acid piperidin-1-ylamide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclohexyl-pyridine-2-carboxylic acid (Example 7 b) and 1-piperidinamine (CAN 2213-43-6) as starting materials, MS (EI): 288.3 [M+H]+.

Sources & evidence

ORD record: ord-f5d778ff018140d2b857f9962a5216ad
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09290451B2

Reaction notes

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