1-Aminopiperidine → 6-(4-Chloro-phenyl)-pyridine-2-carboxylic acid piperidin-1-ylamide

HRID 927426Notes

Reaction equation

HRID 927426 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[N:17]1([NH2:23])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[N:17]1([NH:23][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:16])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 247301366-(4-Chlorophenyl)picolinic acid

Product 1

HCID 710878016-(4-Chloro-phenyl)-pyridine-2-carboxylic acid piperidin-1-ylamide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(4-chlorophenyl)-2-pyridinecarboxylic acid (CAN 135432-77-8) and 1-piperidinamine (CAN 2213-43-6) as starting materials, MS (EI): m/e=316.1 [M+H]+.

Sources & evidence

ORD record
ord-a5b4059a410e471db40c1925036ee8b0
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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