6-(3-Chlorophenyl)picolinic acid → 6-(3-Chloro-phenyl)-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

HRID 927450Notes

Reaction equation

HRID 927450 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH:17]1([CH2:20][C@H:21]([NH:27]C(C2C=CC(C3CCOCC3)=C(OCC3CC3)N=2)=O)[C:22]2[S:23][CH:24]=[CH:25][N:26]=2)[CH2:19][CH2:18]1>>[CH:17]1([CH2:20][C@H:21]([NH:27][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[C:22]2[S:23][CH:24]=[CH:25][N:26]=2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 247301356-(3-Chlorophenyl)picolinic acidHCID 711055706-Cyclopropylmethoxy-5-(tetrahydro-pyran-4-yl)-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

Product 1

HCID 711055716-(3-Chloro-phenyl)-pyridine-2-carboxylic acid ((S)-2-cyclopropyl-1-thiazol-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chlorophenyl)-2-pyridinecarboxylic acid (CAN 863704-38-5) and (S)-2-cyclopropyl-1-thiazol-2-yl-ethylamine (Example 59 b) as starting materials, MS (LC/MS): 384.1 [M+H]+.

Sources & evidence

ORD record
ord-a84c729eac23469481bfa76320cb6a14
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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