(S)-alpha-(2-methylpropyl)-2-thiazolemethanamine → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-3-methyl-1-thiazol-2-yl-butyl)-amide

HRID 927456Notes

Reaction equation

HRID 927456 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[CH3:16][CH:17]([CH3:26])[CH2:18][C@@H:19]([C:21]1[S:22][CH:23]=[CH:24][N:25]=1)[NH2:20]>>[CH3:16][CH:17]([CH3:26])[CH2:18][C@H:19]([NH:20][C:12]([C:10]1[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:21]1[S:22][CH:23]=[CH:24][N:25]=1

Participants

3

Reactant 2

HCID 42078239(S)-alpha-(2-methylpropyl)-2-thiazolemethanamineHCID 710875996-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid

Product 1

HCID 711055746-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-3-methyl-1-thiazol-2-yl-butyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and (S)-α-(2-methylpropyl)-2-thiazolemethanamine (Example 56 d) as starting materials, MS (EI): m/e=360.2 [M+H]+.

Sources & evidence

ORD record
ord-c7f4bcd6563242778c52148cf49c389f
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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