5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid → 5-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 927495Notes

Reaction equation

HRID 927495 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:15]([OH:17])=O)=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=1.[NH2:18][C:19]([CH2:26][CH3:27])([CH2:24][CH3:25])[C:20]([NH:22][CH3:23])=[O:21]>>[CH2:24]([C:19]([NH:18][C:15]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([Cl:14])[CH:9]=2)[N:6]=1)=[O:17])([C:20](=[O:21])[NH:22][CH3:23])[CH2:26][CH3:27])[CH3:25]

Participants

3

Reactant 2

HCID 710876195-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acidHCID 798103702-Amino-2-ethyl-N-methyl-butyramide

Product 1

HCID 711131975-Chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-6-(3-chloro-phenyl)-pyridine-2-carboxylic acid (Example 58 c) and 2-amino-2-ethyl-N-methyl-butyramide (Example 70 b) as starting materials, MS (EI): m/e=394.1 [M+H]+.

Sources & evidence

ORD record
ord-de1777a8d05440c1a26df0bb9e5387e7
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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