6-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid → HCID 71105589, compound

HRID 927503Notes

Reaction equation

HRID 927503 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH:17]2[CH2:19][CH2:18]2)[CH:5]=[CH:6][CH:7]=1.Cl.[NH2:21][C@@H:22]([CH2:26][CH:27]1[CH2:29][CH2:28]1)[C:23]([NH2:25])=[O:24]>>[C:23]([C@@H:22]([NH:21][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH:17]2[CH2:19][CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])[CH2:26][CH:27]1[CH2:29][CH2:28]1)(=[O:24])[NH2:25]

Participants

3

Reactant 2

HCID 710874536-(3-Chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acidHCID 86674760HCID 86674760, compound

Product 1

HCID 71105589HCID 71105589, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-cyclopropyl-pyridine-2-carboxylic acid (Example 48 e) and (S)-2-amino-3-cyclopropyl-propanamide hydrochloride as starting materials, MS (EI): m/e=384.2 [M+H]+.

Sources & evidence

ORD record
ord-5eb61cec824c4397abaf39a50e2b623f
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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