2-(1,3-Thiazol-2-yl)propan-2-amine → HCID 71093521, compound

HRID 927511Notes

Reaction equation

HRID 927511 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH:17]2[CH2:21][CH2:20][O:19][CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[CH3:22][C:23]([CH3:30])([C:25]1[S:26][CH:27]=[CH:28][N:29]=1)[NH2:24]>>[CH3:22][C:23]([NH:24][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH:17]2[CH2:21][CH2:20][O:19][CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:25]1[S:26][CH:27]=[CH:28][N:29]=1)[CH3:30]

Participants

3

Reactant 2

HCID 282862032-(1,3-Thiazol-2-yl)propan-2-amineHCID 71087846HCID 71087846, compound

Product 1

HCID 71093521HCID 71093521, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-(tetrahydro-furan-3-yl)-pyridine-2-carboxylic acid and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (EI): m/e=428.1 [M+H]+.

Sources & evidence

ORD record
ord-ff776b4c2e61448183cbe16439f982a8
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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