HCID 86674762, compound → HCID 86674763, compound

HRID 927517Notes

Reaction equation

HRID 927517 reaction equation
[C:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:12]([OH:14])=[O:13])=[N:10][CH:11]=2)[CH2:5][CH2:4][CH2:3][CH:2]=1>[Pd].CO>[CH:1]1([C:6]2[CH:7]=[CH:8][C:9]([C:12]([OH:14])=[O:13])=[N:10][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 1

HCID 86674762HCID 86674762, compound

Product 1

HCID 86674763HCID 86674763, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 5-cyclopentenyl-pyridine-2-carboxylic acid (2.0 g, 11 mmol) and palladium on carbon (10% w/w, 0.5 g) in methanol (20 mL) under a hydrogen atmosphere was stirred at ambient temperature overnight. The mixture was filtered and the filtrate concentrated in vacuo to give the title compound which was used in the next step without further purification (1.4 g, 72%); MS (EI): m/e=192.1 [M+H]+.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-0b8df2ab6d3c402caf8d3082d836189a
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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