2-(1,3-Thiazol-2-yl)propan-2-amine → HCID 71105605, compound

HRID 927539Notes

Reaction equation

HRID 927539 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[C:15]([F:18])([F:17])[F:16])[CH2:3][CH2:2]1.[CH3:19][C:20]([CH3:27])([C:22]1[S:23][CH:24]=[CH:25][N:26]=1)[NH2:21]>>[CH3:19][C:20]([NH:21][C:12]([C:10]1[CH:9]=[CH:8][C:7]([C:15]([F:18])([F:17])[F:16])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])([C:22]1[S:23][CH:24]=[CH:25][N:26]=1)[CH3:27]

Participants

3

Reactant 2

HCID 282862032-(1,3-Thiazol-2-yl)propan-2-amineHCID 710874576-Cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid

Product 1

HCID 71105605HCID 71105605, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-trifluoromethyl-pyridine-2-carboxylic acid (Example 113 d) and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (EI): m/e=386.0 [M+H]+.

Sources & evidence

ORD record
ord-3e828ccd707c42b3ac6335185554461c
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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