2-(1,3-Thiazol-2-yl)propan-2-amine → 6-(3-Chloro-phenyl)-5-cyclopentyl-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14](O)=[O:15])[CH:11]=[CH:10][C:9]=2[CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[CH3:22][C:23]([CH3:30])([C:25]1[S:26][CH:27]=[CH:28][N:29]=1)[NH2:24]>>[CH3:22][C:23]([NH:24][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:15])([C:25]1[S:26][CH:27]=[CH:28][N:29]=1)[CH3:30]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-cyclopentyl-pyridine-2-carboxylic acid (Example 106 e) and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (EI): m/e=426.1 [M+H]+.
Sources & evidence
- ORD record
- ord-8899f4e33275467cb25afab9df29833e
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09290451B2
Reaction notes
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