Sodium Hydroxide → 5-Cyclopropyl-6-(2-methoxyethoxy)-pyridine-2-carboxylic acid

Participants

Reaction Steps

A solution of 5-cyclopropyl-6-(2-methoxyethoxy)-pyridine-2-carboxylic acid methyl ester (0.16 g, 0.6 mmol) and sodium hydroxide (31 mg, 0.7 mmol) in ethanol (40 mL) was heated to 90° C. for 2 h. The reaction mixture was evaporated, dissolved in water and extracted with ethyl acetate (30 mL). The pH of the aqueous layer was adjusted to 2 by addition of 1 N hydrochloric acid, the resulting precipitate was collected by filtration and dried in vacuo to give the title compound (0.11 g, 0.5 mmol; 73%) as yellow oil; MS: m/e=238.1 [M+H]+.

Provenance & Evidence