Leucinamide → HCID 71105630, compound

HRID 927592Notes

Reaction equation

HRID 927592 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:18]([OH:20])=O)=[N:8][C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[CH2:3][CH2:2]1.[NH2:21][C@@H:22]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:23]([NH2:25])=[O:24]>>[C:23]([C@@H:22]([NH:21][C:18]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=2)[N:8]=1)=[O:20])[CH2:26][CH:27]([CH3:29])[CH3:28])(=[O:24])[NH2:25]

Participants

3

Reactant 2

HCID 69640LeucinamideHCID 710876985-Cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid

Product 1

HCID 71105630HCID 71105630, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(4-fluoro-benzyl)-pyridine-2-carboxylic acid and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials, MS (EI): m/e=384.2 [M+H]+.

Sources & evidence

ORD record
ord-e1802998b1fb4b3f94fe0981caaf8f5c
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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