2-(1,3-Thiazol-2-yl)propan-2-amine → 6-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

HRID 927593Notes

Reaction equation

HRID 927593 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14](O)=[O:15])[CH:11]=[CH:10][C:9]=2[N:17]2[CH2:20][C:19]([F:22])([F:21])[CH2:18]2)[CH:5]=[CH:6][CH:7]=1.[CH3:23][C:24]([CH3:31])([C:26]1[S:27][CH:28]=[CH:29][N:30]=1)[NH2:25]>>[CH3:23][C:24]([NH:25][C:14]([C:12]1[CH:11]=[CH:10][C:9]([N:17]2[CH2:20][C:19]([F:21])([F:22])[CH2:18]2)=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:15])([C:26]1[S:27][CH:28]=[CH:29][N:30]=1)[CH3:31]

Participants

3

Reactant 2

HCID 282862032-(1,3-Thiazol-2-yl)propan-2-amineHCID 710876736-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid

Product 1

HCID 711056316-(3-Chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (1-methyl-1-thiazol-2-yl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 140 a) and α,α-dimethyl-2-thiazolemethanamine (CAN 1082393-38-1) as starting materials, MS (EI): m/e=449.1 [M+H]+.

Sources & evidence

ORD record
ord-7b44db1e17b84f4ea2b520c61dd95363
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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