2-Amino-2-ethyl-N-methyl-butyramide → 5-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 927610Notes

Reaction equation

HRID 927610 reaction equation
[F:1][C:2]([F:25])([F:24])[CH2:3][N:4]([CH2:19][C:20]([F:23])([F:22])[F:21])[C:5]1[CH:6]=[CH:7][C:8]([C:16](O)=[O:17])=[N:9][C:10]=1[O:11][CH2:12][CH:13]1[CH2:15][CH2:14]1.[NH2:26][C:27]([CH2:34][CH3:35])([CH2:32][CH3:33])[C:28]([NH:30][CH3:31])=[O:29]>>[CH2:32]([C:27]([NH:26][C:16]([C:8]1[CH:7]=[CH:6][C:5]([N:4]([CH2:3][C:2]([F:1])([F:25])[F:24])[CH2:19][C:20]([F:22])([F:21])[F:23])=[C:10]([O:11][CH2:12][CH:13]2[CH2:14][CH2:15]2)[N:9]=1)=[O:17])([C:28](=[O:29])[NH:30][CH3:31])[CH2:34][CH3:35])[CH3:33]

Participants

3

Reactant 2

HCID 798103702-Amino-2-ethyl-N-methyl-butyramideHCID 866747745-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 866747755-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-[bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 162 b) and 2-amino-2-ethyl-N-methyl-butyramide (Example 70 b) as starting materials, MS (EI): m/e=499.2 [M+H]+.

Sources & evidence

ORD record
ord-c5fe3bcc33cf4b7f838caba4d7ebadce
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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