HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Methyl-1,2,4-oxadiazol-3-yl)cyclobutan-1-amine hydrochloride → 5-Cyclopropyl-6-(cyclopropylmethoxy)-N-(1-(5-methyl-1,2,4-oxadiazol-3-yl)cyclobutyl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Methyl-1,2,4-oxadiazol-3-yl)cyclobutan-1-amine hydrochloride | HCID 42959052 | — |
| Reactant | 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 71087346 | — |
| Product | 5-Cyclopropyl-6-(cyclopropylmethoxy)-N-(1-(5-methyl-1,2,4-oxadiazol-3-yl)cyclobutyl)picolinamide | HCID 71087464 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and 1-(5-methyl-1,2,4-oxadiazol-3-yl)-cyclobutanamine hydrochloride (1:1) (CAN 1170897-28-5) as starting materials, LC-MS (UV peak area/ESI) 97.8%, 369.1914 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290451B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-c9b8cbcc16c04363aedae1aeb6002f46 |
| Source note | uspto-grants-2016_03 |