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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927620Generated: November 1, 2026

(R)-2-Amino-2-phenylacetamide hydrochloride → (R)-N-(2-Amino-2-oxo-1-phenylethyl)-5-cyclopropyl-6-(cyclopropylmethoxy)picolinamide

https://huagongshe.com/reaction/927620

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-2-Amino-2-phenylacetamide hydrochlorideHCID 16216957—
Reactant5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 71087346—
Product(R)-N-(2-Amino-2-oxo-1-phenylethyl)-5-cyclopropyl-6-(cyclopropylmethoxy)picolinamideHCID 71087216—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and (αR)-α-amino-benzeneacetamide hydrochloride (1:1) (CAN 63291-39-4) as starting materials, LC-MS (UV peak area/ESI) 100%, 366.1808 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290451B2
Source datasetuspto-grants-2016_03
ORD IDord-d9e2eddbac5b402990fc4743b0025f16
Source noteuspto-grants-2016_03