D(-)-Leucinol → HCID 71087589, compound

HRID 927621Notes

Reaction equation

HRID 927621 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C@H:19]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH2:20][OH:21]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([NH:18][C@H:19]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH2:20][OH:21])=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 2724002D(-)-LeucinolHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 71087589HCID 71087589, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and (2R)-2-amino-4-methyl-1-pentanol (CAN 53448-09-2) as starting materials, LC-MS (UV peak area/ESI) 100%, 333.2165 (M+H)+.

Sources & evidence

ORD record
ord-42bf7b9ab253438f9cf67d61e1d47425
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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