5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid → HCID 71087591, compound

HRID 927628Notes

Reaction equation

HRID 927628 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@@H:20]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:21]([NH:23][CH3:24])=[O:22]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([NH:19][C@@H:20]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:21]([NH:23][CH3:24])=[O:22])=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 86674777HCID 86674777, compound

Product 1

HCID 71087591HCID 71087591, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and (2S)-2-amino-N,4-dimethyl-pentanamide monohydrochloride (CAN 99145-71-8) as starting materials, MS (D): m/e=360.1 [M+H]+.

Sources & evidence

ORD record
ord-b3498feb86e94d90bd18c154d89ea364
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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