5-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid → HCID 71087615, compound

HRID 927631Notes

Reaction equation

HRID 927631 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[CH2:3][CH2:2]1.Cl.[NH2:21][C@@H:22]([CH2:27][CH:28]([CH3:30])[CH3:29])[C:23]([NH:25][CH3:26])=[O:24]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([NH:21][C@@H:22]([CH2:27][CH:28]([CH3:30])[CH3:29])[C:23]([NH:25][CH3:26])=[O:24])=[O:19])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 710872545-Cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acidHCID 86674777HCID 86674777, compound

Product 1

HCID 71087615HCID 71087615, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 166 b) and (2S)-2-amino-N,4-dimethyl-pentanamide monohydrochloride (CAN 99145-71-8) as starting materials, MS (EI): m/e=390.0 [M+H]+.

Sources & evidence

ORD record
ord-104eade77a78475bb9471a52a1ff284e
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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