HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium cyclopropyltrifluoroborate → N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-cyclopropyl-6-((tetrahydrofuran-2-yl)methoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium cyclopropyltrifluoroborate | HCID 23697338 | — |
| Reactant | 5-Bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide | HCID 71105643 | — |
| Product | N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-5-cyclopropyl-6-((tetrahydrofuran-2-yl)methoxy)picolinamide | HCID 71087442 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 166 b, using 5-bromo-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide (Example 186 a) and potassium cyclopropyltrifluoroborate as starting materials, MS (EI): m/e=376.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290451B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-95d2cd1dd90d4996a3ecb2152d2ac34d |
| Source note | uspto-grants-2016_03 |