Potassium cyclopropyltrifluoroborate → HCID 71105642, compound

HRID 927635Notes

Reaction equation

[C:1]([C@@H:4]([NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15](Br)=[C:14]([O:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[N:13]=1)=[O:11])[CH2:5][CH:6]([CH3:8])[CH3:7])(=[O:3])[NH2:2].[CH:27]1([B-](F)(F)F)[CH2:29][CH2:28]1.[K+]>>[C:1]([C@@H:4]([NH:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([CH:27]2[CH2:29][CH2:28]2)=[C:14]([O:19][C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)[N:13]=1)=[O:11])[CH2:5][CH:6]([CH3:8])[CH3:7])(=[O:3])[NH2:2]

Participants

Reactant 2

HCID 23697338Potassium cyclopropyltrifluoroborate

HCID 71105640HCID 71105640, compound

Product 1

HCID 71105642HCID 71105642, compound

Procedure

The title compound was synthesized in analogy to Example 166 b, using 5-bromo-6-(4-fluoro-phenoxy)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide (Example 177 b) and potassium cyclopropyltrifluoroborate as starting materials, MS (EI): m/e=386.0 [M+H]+.

Sources & evidence

ORD record: ord-966347f0d7cf43ac9d60363ef4967f15
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09290451B2

Reaction notes

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