HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-amino-2-ethylbutanoate hydrochloride → 2-([5-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carbonyl]-amino)-2-ethyl-butyric acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-amino-2-ethylbutanoate hydrochloride | HCID 75488114 | — |
| Reactant | 5-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 86674774 | — |
| Product | 2-([5-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carbonyl]-amino)-2-ethyl-butyric acid methyl ester | HCID 71491228 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-[bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 162 b) and methyl 2-amino-2-ethylbutanoate hydrochloride (CAN 92398-54-4) as starting materials, MS (EI): m/e=500.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290451B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-d15e78fe76ce49f990ac143c846ddbb9 |
| Source note | uspto-grants-2016_03 |