HCID 26249014, compound → HCID 71105663, compound

HRID 927679Notes

Reaction equation

HRID 927679 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)[CH2:3][CH2:2]1.[F:21][C:22]([F:32])([F:31])[C@H:23]([NH2:30])[C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1>>[F:32][C:22]([F:21])([F:31])[C@H:23]([NH:30][C:12]([C:10]1[CH:9]=[CH:8][C:7]([N:15]2[CH2:18][C:17]([F:20])([F:19])[CH2:16]2)=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 26249014HCID 26249014, compoundHCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid

Product 1

HCID 71105663HCID 71105663, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-(3,3-difluoro-azetidin-1-yl)-pyridine-2-carboxylic acid (Example 69 b) and (R)-2,2,2-trifluoro-1-pyridin-3-yl-ethylamine (CAN 1212813-98-3) as starting materials. MS (EI): m/e=443.1 [M+H]+.

Sources & evidence

ORD record
ord-7405ec2c915b40b5936cef4e3c0d8f78
Source dataset
uspto-grants-2016_03
Patent number
US09290451B2

Reaction notes

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