Sodium Hydroxide → 2-(6-(Cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoic acid

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Reaction Conditions

Reaction Steps

Ethyl 2-(6-(cyclopropylmethoxy)-5-(trifluoromethyl)picolinamido)-2-ethylbutanoate (62 mg, 154 μmol) was dissolved in a mixture of 1 M aqueous sodium hydroxide solution (616 μL, 616 μmol), THF (600 μL) and MeOH (600 μL). The mixture was stirred at 60° C. for 3 d, poured onto ice water/brine/1N HCl (20 mL) and extracted with EtOAc (2×30 mL). The combined extracts were washed with ice water/brine (20 mL) and dried over Na2SO4. The solvent was removed in vacuo to give the title compound (58 mg, quant.) as a light yellow solid. MS: 373.1 [M−H]−.

Provenance & Evidence